CD274 and cancer: Similarly, KEGG enrichment analysis also recognized some signaling pathways associated with immune and relevant diseases such as PD-L1 expression and PD-1 checkpoint pathway in cancer, allograft rejection, primary immunodeficiency, etc. (Figures 8D–F) These results allow us to reasonably infer that immune-relevant pathways and functions are significantly different in the high-OS and low-OS groups and may be responsible for the poor prognosis of the invalids.