GSEA revealed that as compared to low-OS group, various immune-relevant signaling pathways (Figures 10A, B) includes B cell receptor signaling pathway (Figure 10C), complement activation (Figure 10D), immunoglobulin receptor binding (Figure 10E), immunoglobulin complex, circulating (Figure 10F), humoral immune response mediated by circulating immunoglobulin (Figure 10G), antigen processing and presentation (Figure 10H), primary immunodeficiency (Figure 10J) etc., were downregulated in the high-OS group. Here, PPIB is linked to inborn error of immunity.