Furthermore, a combination of clinically subtherapeutic concentrations of mitotane with 1,25(OH)2D, had an additive anti-proliferative effect, thus showing an additive effect of mitotane and 1,25(OH)2D on inhibition growth of H295R ACC cells and suggested the presence of a functional link between the VDR and Wnt/beta-catenin pathways (33). The gene discussed is VDR; the disease is adrenal cortex carcinoma.