PRL and hyperprolactinemia: The objectives of this study are to i) develop an XGBoost model for the detection of PRL levels in OLZ-treated patients, and ii) identify multiple factors, particularly co-administered drugs, that may cause hypo- or hyperprolactinemia during OLZ treatment by using an interpretable ML method–the SHapley Additive exPlanations (SHAP) analysis (35).