TRH and central nervous system disorder: PRL secretion is regulated by stimulatory factors like the thyrotropin-releasing hormone (TRH) and inhibitory factors like dopamine (DA) in the hypothalamus, and is influenced by alterations in both physiological (e.g., pregnancy, stress, and sleep states) and pathological conditions (e.g., pituitary disorders, central nervous system disorders, and systemic diseases) (2, 3).