Specifically, the nodes located in the central core of the graph, MNTR1B (rs1387153, rs10830962, rs10830963), IGF2BP2 (rs4402960, rs7651090), KCNJ11 (rs5215), GCKR (rs780094), CDKAL1 (rs9368222), IRS1 (rs2943634), ADRA2A (rs10885122), CRY2(rs11605924), DKGB (rs2191349), G6PC2 (rs563694), GLIS3 (rs7041847, rs7034200, rs10814916), GIPR (rs2302593), WFS1 (rs4458523), ZBED3 (rs7708285), PROX1 (rs340874), FOXA2 (rs6048205), PDX1 (rs2293941), PCSK1 (rs6235), have been referred in various GWAS as associated to diabetes (6, 19–25), GDM (26–34) or both (35, 36). This evidence concerns the gene IRS1 and diabetes mellitus.