The genetic variants significantly associated with increased risk of GDM were rs4402960, rs7651090, IGF2BP2; rs1387153, rs10830963, rs10830962, MTNR1B; rs17676067, GLP2R, rs1371614, DPYSL5; rs5215, KCNJ11; and rs2293941, PDX1. The gene discussed is KCNJ11; the disease is gestational diabetes.