The identification of the FET-CREB fusions as drivers in these cancers provides important validation of the role of CREB family members in oncogenesis; however, many questions remain, including the question of whether phosphorylation of the CREB family member incorporated in the fusion is required for the oncogenic activity of the fusion, and, if so, whether that phosphorylation is mediated by PKA, as opposed to ERK1/2, or possibly other kinases. This evidence concerns the gene CREB1 and cancer.