Tg is a homodimeric macromolecular glycoprotein secreted by the thyroid follicular epithelial cells, which is intimately correlated with postoperative residual thyroid tissue and/or residual tumor tissue along with remission, persistence, recurrence, or distant metastasis of disease after the initial treatment, and can be considered as an essential indicator for monitoring tumor recurrence and metastasis (10). The gene discussed is TG; the disease is neoplasm.