The order of these three variables to predict LN metastasis was CNV followed by tumor size followed by BRAF. The area under the curve (AUC) of CNV was 0.733 (95% CI 0.574 to 0.892), which was higher than that of tumor size (AUC 0.668, 95% CI 0.496 to 0.840) and BRAF (AUC 0.534, 95% CI 0.352 to 0.715) for all patients In addition, as shown in Table 6, the prediction performance is significantly higher than that of BRAF (p=0.015). The gene discussed is BRAF; the disease is neoplasm.