Recently, researchers reported that triggering an accumulation of ceramide by inhibition of sphingosine kinase induced an apoptotic integrated stress response in AML cells, leading to transcription of the BH3-only protein NOXA and degradation of the prosurvival MCL-1 protein, which may overcome BCL-2 inhibitor resistance (104). The gene discussed is BCL2; the disease is acute myeloid leukemia.