Recently, researchers reported that triggering an accumulation of ceramide by inhibition of sphingosine kinase induced an apoptotic integrated stress response in AML cells, leading to transcription of the BH3-only protein NOXA and degradation of the prosurvival MCL-1 protein, which may overcome BCL-2 inhibitor resistance (104). This evidence concerns the gene MCL1 and acute myeloid leukemia.