For those with HPV infection (12, 46, 60), SCC (60), advanced stage (46, 60), large tumor size (61), poorly differentiated tumors (61), metastatic tumors (60), history of multiple childbearing and abortion (57), and previous history of receiving chemotherapy (46), a high expression of PD-L1 might be observed, thus suggestion potential beneficiaries for anti-PD-1/PD-L1 treatment. This evidence concerns the gene CD274 and metastatic neoplasm.