In this study, the immunosuppressive behavior mediated by CAF was attributed to the secretion of Galectin-1 (Gal1), which was noted within the captured transcriptome by the substantial expression of LGALS1. Gal1, a well-known immunosuppressor within various tumor microenvironments, mediates apoptosis of cytotoxic CD8+ T cells. This evidence concerns the gene CD8A and neoplasm.