PBRM1 and nonpapillary renal cell carcinoma: Similarly, in humans, the development of ccRCC has been reported in PTEC with altered VHL, following additional inactivation of polybromo 1 (PBRM1), BRCA-associated protein 1 (BAP1), and/or SET domain containing 2 (SETD2) genes (12, 17, 19).