Further ligand–receptor gene inferencing revealed an increase in immune checkpoint interactions such as PD-L1-PD-1, CD80/CD86-CTLA4, NECTIN2/PVR-TIGIT, LGALS9-TIM-3, TNFRSF14-BTLA, and SPP1-CD44 between M2-like TAMs and exhausted CD8+ T cells, in advanced ccRCC (43). This evidence concerns the gene HAVCR2 and nonpapillary renal cell carcinoma.