The gene expression levels of AOC1 (P = 0.008, Figure 1F), MT-CO1 (P < 0.001, Figure 1N), and ACO1 (P = 0.007, Figure 1O) were significantly descended in HCC samples by comparing 58 paired HCC samples and adjacent normal liver samples in paired differential analysis, other genes were notably ascended in HCC samples (Figure 1). The gene discussed is MT-CO1; the disease is hepatocellular carcinoma.