These results suggested that FDX1, LIPT1, DLAT, PDHA1, MTF1, MT-CO1, ACO1, SCO2, ATP7A, SLC25A3, AOC1, COA6, TMEM199, ATP6AP1, ACP1, FDX2, NUBP2, CIAPIN1, ISCA2, and NDOR1 may serve as prognostic markers and potential therapeutic targets in HCC, which were not summarized in other bioinformatic analysis research of HCC. This evidence concerns the gene SCO2 and hepatocellular carcinoma.