MCAT and Wilson disease: Chronic liver injury spontaneously developed into liver cancer for copper accumulation and MT protein induction in the liver of Long Evans Cinnamon (LEC) rats (exhibiting human Wilson’s disease), with consistently, copper accumulation may inhibit the growth of surrounding liver cells, whereas the cells in injured liver tissues escape the effects of copper toxicity by increasing MT protein induction and decreasing copper accumulation to achieve proliferation (46).