Whereas the gene expressions of ATP7A, SLC25A3, SCO2, COA6, TMEM199, ATP6AP1, LIPT1, DLAT, PDHA1, MTF1, ACP1, FDX2, NUBP2, CIAPIN1, ISCA2, and NDOR1 in HCC tissues were prominently higher than their surrounding tissues, and the differences were all statistically significant (P < 0.001, Figure 2). Here, ISCA2 is linked to hepatocellular carcinoma.