Some signaling pathways (such as natural killer cell mediated cytotoxicity, oxidative phosphorylation, TCA cycle, glutathione metabolism, protein export, ABC transporters, ubiquitin mediated proteolysis, apoptosis, pathways in cancer, Notch signaling pathway, JAK/STAT signaling pathway, ErbB signaling pathway, metabolism of xenobiotics by cytochrome p450, as well as complement and coagulation cascades) that differentially enriched in high or low expression of twenty screened cuproptosis-related genes were more comprehensively reported in the present study. The gene discussed is ABCG2; the disease is cancer.