Hereditary hemochromatosis, hepatitis C virus, and hepatitis B virus could directly create HCC in the absence of cirrhosis, whereas HCC patients with other underlying liver diseases (such as primary biliary cirrhosis, autoimmune hepatitis, nonalcoholic steatohepatitis, Wilson disease, and alpha 1-antitrypsin deficiency) often suffer from cirrhosis, so treating the potential liver diseases and reducing the progression of cirrhosis may decline the incidence of HCC (3). The gene discussed is SERPINA1; the disease is hepatocellular carcinoma.