Moreover, the natural killer cell mediated cytotoxicity, oxidative phosphorylation, TCA cycle, glutathione metabolism, protein export, ABC transporters, ubiquitin mediated proteolysis, apoptosis, pathways in cancer, Notch signaling pathway, JAK/STAT signaling pathway, ErbB signaling pathway, metabolism of xenobiotics by cytochrome p450, and complement and coagulation cascades may be the key pathways controlled by cuproptosis-related genes in HCC. Here, EGFR is linked to hepatocellular carcinoma.