PBXIP1 and ovarian neoplasm: In addition, hematopoietic PBX interacting protein (HPIP) was overexpressed in high-grade primary ovarian tumors, which increased Snail stability by activating the PI3K/AKT pathway and inhibiting the expression of E-cadherin by phosphorylating glycogen synthase kinase-3β (GSK-3β), thereby inducing EMT.