A total of 9 hub genes had been screened, among which 2 genes were up-regulated in ccRCC tissues (ENO2,LOX), whereas the remaining 7 genes (AQP2, EGF, SLC34A1, SLC12A3, SLC12A1, CLCNKB, PLG) were overexpressed in non-cancerous tissues (Table 1). The gene discussed is PLG; the disease is nonpapillary renal cell carcinoma.