Specifically, c-MYC induces high expression of pyruvate kinase (PK) M2 (PKM2) (an isoform of PK) in MM cells, through the never-in mitosis (NIMA) related kinase 2 (NEK2), which governs chromosome segregation in the G2/M phase of the cell cycle (45). This evidence concerns the gene MYC and Miyoshi myopathy.