Based on these findings, the FoxO1-miR-148a-5p-CREB1 axis is involved in STAT3-mediated regulation of SRGN and the promotion of nasopharyngeal cancer growth and metastasis, thereby confirming the role of STAT3 in the proliferation, invasion, and anti-apoptotic effects of NPC cells. The gene discussed is FOXO1; the disease is nasopharyngeal carcinoma.