Based on these findings, the FoxO1-miR-148a-5p-CREB1 axis is involved in STAT3-mediated regulation of SRGN and the promotion of nasopharyngeal cancer growth and metastasis, thereby confirming the role of STAT3 in the proliferation, invasion, and anti-apoptotic effects of NPC cells. This evidence concerns the gene CREB1 and nasopharyngeal carcinoma.