There is some research showing that in non-small-cell lung cancer (NSCLC) TP53R175H can induce expression of miRNA-128-2, which acts on E2F5 after transcription, resulting in loss of its inhibitory effect on transcription of p21 (waf1) in the cytoplasm and prevention of an anti-apoptotic effect by cleavage of caspase-3 (78). The gene discussed is CDKN1A; the disease is non-small cell lung carcinoma.