In esophageal cancer and small cell lung cancer, TP53 controls transcription of GPX4 and SLC7A11 via nuclear factor erythroid 2-related factor 2 (NRF2), which is sensitive to drug-induced oxidative stress (54) and regulates ferroptosis by controlling the transcriptional expression of GPX4 and SLC7A11 (55). The gene discussed is GPX4; the disease is esophageal cancer.