HUWE1 and neoplasm: After a comprehensive analysis, we found that the expressions of CBLB, FBXW7, HUWE1, ITCH, SIAH2, STUB1, SYVN1, TRM2B, and UBR5 were significantly upregulated; MARCH1, RNF128, and TRAF6 were significantly downregulated; and ASB2 had no obvious difference between tumor and paracarcinoma (Figure 1A).