However, in COAD, acute myeloid leukemia (LAML), and READ, a higher level of MARCH1 meant significantly higher MSI, while in diffuse large B-cell lymphoma (DLBC), KIRP, LUAD, LUSC, SKCM, and testicular germ cell tumors (TGCT), the opposite trend was observed (Figure 8F). The gene discussed is MARCHF1; the disease is colon adenocarcinoma.