The combined nomogram yielded an incremental performance in predicting the Ki-67 expression of HCC; the C-index was 0.919 (95% CI, 0.858–0.970) in the training, 0.925 (95% CI, 0.821–1.000) in the validation cohort, and 0.850 (95% CI, 0.736–0.952) in the external validation group. Here, MKI67 is linked to hepatocellular carcinoma.