With regards to other components of the corepressor complex, the RBPJ and SNW1 gene loci were found to be recurrently deleted in high-risk CLL (minimally deleted regions: del (4)(p15.1-p15.2) for RBPJ loss; del (14)(q24.3-q32.1) for SNW1 loss). Here, RBPJ is linked to B-cell chronic lymphocytic leukemia.