FGL2 and central nervous system cancer: The migratory effect of macrophages was also significantly suppressed after blocking FGL2 or using antibody blockers of the FGL2 receptor FcγRIII (CD16) (23).These findings suggest that FGL2 acts as a potent chemokine that recruits macrophages into the tumor microenvironment (TME) of gliomas, and CD16 is the receptor that mediates this chemotactic effect.