showed direct cell to cell contact between ductal breast carcinoma in situ (DCIS) cancer cells and fibroblasts induces changes in the expression profile of fibroblasts, eventually resulting in a platelet-derived growth factor (PDGF) receptor (PDGFR)α low, PDGFRβ high subset of CAFs (22). The gene discussed is PDGFRA; the disease is ductal breast carcinoma in situ.