A growing number of studies revealed that TMEMs were differentially expressed among human cancers, including TMEM116 and TMEM229A in lung cancer (29, 30), TMEM205 in hepatocellular carcinoma (31), TMEM168 in glioblastoma (32), and TMEM180 in colorectal cancer (33). The gene discussed is TMEM116; the disease is hepatocellular carcinoma.