Notably, using an ATF6-specific inducer (i.e., compound 147), Blackwood et al. found that activation of the ATF6 pathway exerts protective effects in various mouse ischemia/reperfusion models including heart ischemia, renal ischemia, and ischemic stroke, demonstrating that ATF6 signaling is likely a universal pro-survival pathway that protects cells from ischemic injury (Blackwood et al., 2019). The gene discussed is ATF6; the disease is ischemic stroke.