In support of the implication of NPAS3 in neuropsychiatric and neurodevelopmental disorders, mouse knockout models of Npas3 display a range of behavioral phenotypes including locomotor hyperactivity, subtle gait defects, memory problems, and impairment of prepulse inhibition (Erbel-Sieler et al., 2004; Brunskill et al., 2005; Pieper et al., 2005). Here, NPAS3 is linked to neurodevelopmental disorder.