PVT1 controls ferroptosis associated with cerebral ischemia/reperfusion (I/R) via miR-214-mediated regulation of TFR1 and TP53 expression, while ketamine regulates ferroptosis in hepatoma cells via lncRNA PVT1 (Lu et al., 2020; He G. N. et al., 2021). This evidence concerns the gene TP53 and hepatocellular carcinoma.