TMPRSS11A and obesity due to melanocortin 4 receptor deficiency: The protective potential of Hesp has been suggested in semen and the male reproductive system as supplementary material by alleviating oxidative stress responses, inhibiting lipid accumulation and obesity without any toxic effects even at high dosages for an extended period of administration (Shen et al., 2019; Shin et al., 2011; Hozayen, 2012).