In the PTTG3P/miR-383/CCND1-PARP2 axis, PTTG3P acts as a sponge of miR-383 to enhance the expression of PARP2 and CCND1, along with the PI3K/Akt pathway, which potentiates HCC development. This evidence concerns the gene AKT1 and hepatocellular carcinoma.