When comparing average gene expression of cell type signature genes between VAT and SAT (Figure 2E), we identified several DEGs that were depot-specific, such as the increased expression of FASN in SAT AD subpopulations compared with VAT, the increased expression of ME-markers WT1, UPK3B, and MSLN in VAT compared with SAT, and the decreased expression of CD68 and S100A12 in SAT MAC compared with VAT. The gene discussed is UPK3B; the disease is Alzheimer disease.