MAC2 were enriched for CD163, a marker for perivascular macrophage, TGFBI, MRC1/CD206, and F13A1. Both, CD206+ and F13A1+ macrophages, have been associated with AT dysfunction, pro-inflammatory responses, and AT remodeling in human obesity (Kaartinen et al., 2021; Muir et al., 2022). Here, TGFBI is linked to obesity due to melanocortin 4 receptor deficiency.