Tau pathology is correlated to cognitive deficits in patients which, was confirmed by histopathological examination of post-mortem brain and Tau PET imaging (Tomlinson et al., 1970; Alafuzoff et al., 1987; Braak & Braak, 1991; Arriagada et al., 1992; Bierer et al., 1995; Ossenkoppele et al., 2016; Pontecorvo et al., 2019). The gene discussed is MAPT; the disease is Cognitive impairment.