Both NRF2 and FOXO1 are controlled by the master regulator of cell survival AKT (Nakaso et al., 2003; DeNicola et al., 2011; Koundouros and Poulogiannis, 2018) and indeed, we showed here that AKT is crucial for the induction of erythropoiesis from HE cells. The gene discussed is NFE2L2; the disease is hereditary elliptocytosis.