Since 2015, however, de novo mutations in several PP2A genes have been implicated as causative for neurodevelopmental or other inborn brain disorders (Houge et al., 2015; Loveday et al., 2015; Sandal et al., 2021; Verbinnen et al., 2021), while some inherited mutations in other PP2A genes mainly affected development of other organs (Guran et al., 2019). This evidence concerns the gene PTPA and brain disorder.