PPP2R2B and cerebellar ataxia: In contrast, mutations in PPP2R3C (encoding the regulatory B′′γ or G5PR subunit) were found to be mainly associated with deficits in gonadal development (Guran et al., 2019) (Figure 3D), and mutations in the promotor of PPP2R2B (encoding B55β) with spinocerebellar ataxia (Holmes et al., 1999).