In addition to sensory triggers, a peptide trigger, pituitary adenylate cyclase-activating polypeptide-38 (PACAP38), which was reported to induce migraine-like headaches in migraine patients (Schytz et al., 2009; Ghanizada et al., 2020), decreased right cerebellar functional connectivity with default mode network in the early phase of migraine attacks (Amin et al., 2016). Here, ADCYAP1 is linked to migraine disorder.