Bilateral lesion of the MN in juvenile rats was shown to alter anxiety in adulthood although it was not clear whether the anxiety was enhanced or decreased (Helgers et al., 2020), accompanied by enhancement of local field coherence between the medial prefrontal cortex and the sensorimotor cortex (Helgers et al., 2020) and epigenetic dysregulation of the GABAergic system in the nucleus accumbens and the oxytocin system in the prefrontal cortex (Helgers et al., 2021). The gene discussed is OXT; the disease is Anxiety.