For example, when testing for causes of rhabdomyolysis and exercise intolerance, the gene panel may need to include genes associated with metabolic myopathies (glycogen-storage disorders, fatty acid metabolic disorders, and mitochondrial respiratory chain disorders) (79), as well as genes not typically considered to cause a metabolic myopathy but which can result in similar clinical features, such as dystrophies (80), RYR1 (81), or channelopathies (82). This evidence concerns the gene RYR1 and metabolic myopathy.