ZEB1 and cancer: Among the crucial outcomes of cancer cell progression to metastatic phenotype acquisition is the EMT.57 Several miRNAs have been suggested to regulate the expression of genes involved in the EMT, and a reduction in their expression leads to cancer invasion and metastasis.58 For example, miRNA-200b targets the zinc-finger E-box-binding homeobox 1 and 2 genes (ZEB1 and ZEB2), Bim1, and E-cadherin.