Ma et al. showed that miRNA-143 decreases the proliferation and induces the apoptosis of LNCaP cells by suppressing the expression of the integral outer mitochondrial membrane protein BCL2, which inhibits cell death.55 A study by Ostadrahimi et al. demonstrated that miRNA-185, miRNA-30c, and miRNA-1266 were downregulated in PC tissues compared to healthy control tissues,56 resulting in antiapoptotic BCL2 and BCL2-XL gene upregulation and a reduced apoptosis rate.56 Here, BCL2 is linked to pachyonychia congenita.