Aptamers are short single-stranded DNA or RNA oligonucleotides with a unique three-dimensional structure that enables its selective binding to specific receptors or protein targets,91 making them excellent drug delivery platforms.92 Conjugation of aptamers to miRNAs is a new method to deliver miRNAs precisely to PC cells.93 Dassie et al. developed an RNA aptamer (A9 g) that selectively inhibited PSMA enzyme activity and functioned as a smart drug for PC treatment. Here, FOLH1 is linked to pachyonychia congenita.