On the basis of the merged GSE5406, and GSE57338 expression profiling datasets, we determined five RBPs (EIF1AY, RPS4Y1, DDX3Y, RNASE2, and CSDC2) with adjusted p < 0.05 and |fold-change|>1.5 in heart failure LV myocardium specimens than nonfailing controls, which were regarded as hear failure-specific RBPs. This evidence concerns the gene RPS4Y1 and heart failure.