For example, microRNA-143-3p can limit colorectal cancer metastases (Guo et al., 2019), microRNA-375-3p can boost chemosensitivity to 5-fluorouracil through targeting thymidylate synthase in colorectal cancer (Xu et al., 2020), microRNA-451a influences colorectal cancer proliferation (Ruhl et al., 2018), and microRNA-146a can inhibit tumorigenic inflammation of colorectal cancer (Garo et al., 2021). This evidence concerns the gene TYMS and colorectal cancer.