The main enrichment pathways in ARID1B negatively associated genes were: (Wang et al., 2020) metabolic pathway; (Siegel et al., 2022) RNA polymerase, Huntington disease, Parkinson disease, Alzheimer disease; (Zhang et al., 2020a) Thermogenesis; (Cheng et al., 2021) non-alcoholic fatty liver disease; (Han and Yoon, 2012) spliceosome; (Zebley et al., 2021) oxidative phosphorylation; (Li et al., 2014) retrograde endocannabinoid signaling; (Zhou et al., 2019) oxidative phosphorylation (Figures 8A–D). The gene discussed is ARID1B; the disease is early-onset autosomal dominant Alzheimer disease.