CTLA4 and colon adenocarcinoma: Therefore, we evaluated the immunomodulators level related to ARID1B expression in COAD and found a positive correlation of different immunosuppressors, including HAVCR2 (TIM3), LAG3, PDCD1 (PD-1), TIGIT, CD27, CTLA-4, and TNFRSF9 (markers of T cell failure) (Table 3).