DDX5 and hepatocellular carcinoma: In addition, studies have indicated that DDX5 plays a crucial role in tumorigenesis in a wide range of malignancies (Janknecht, 2010), including hepatocellular carcinoma (Xue et al., 2018; Mani et al., 2020), breast cancer (Hashemi et al., 2019), prostate cancer (Taniguchi et al., 2016), and thyroid cancer (Lan et al., 2022), and functions in numerous signaling pathways, including the Wnt/β-Catenin signaling pathway (Wang et al., 2015) and the Akt signaling pathway (Xue et al., 2018).