TP53 and cancer: As a nucleocytoplasmic shuttling protein (Wang et al., 2009), DDX5 regulates the cell cycle by controlling the expression of p53 to induce DNA damage and cell cycle arrest, which prevents apoptosis and induces cellular survival (Nicol et al., 2013).Analysis of the co-expressed genes of DDX5 revealed that DDX5 and its co-expressed genes were significantly positively associated in various cancer types.