In this study, we used a case-control study model in 183 leprosy cases and 185 controls to investigate whether leprosy patients and the control group in southern Brazil have different frequencies in TLR1 (TLR1 G>T; rs5743618), TLR2 (TLR2 T>C, rs1816702 and rs4696483) and TLR4 (TLR4 A>G, rs1927911) polymorphisms (Table 3). This evidence concerns the gene TLR2 and leprosy.