PIK3CA and hepatocellular carcinoma: In hepatocellular carcinoma, c-Myc (MYC) activates WDR4 transcription and facilitates the stability and translation of CCNB1 mRNA through m7G modification, affecting the phosphorylation of PI3K and AKT and promoting P53 ubiquitination, ultimately fueling the progression of hepatocellular carcinoma (Chen Z. et al., 2021).