METTL1 and cancer: METTL1 and WDR4 are upregulated in various types of cancers, which are associated with poor prognosis in patients with cancers such as esophageal squamous cell carcinoma (Han et al., 2022), intrahepatic cholangiocarcinoma (Dai et al., 2021), and nasopharyngeal carcinoma (Chen et al., 2022).