FNDC1 (fibronectin type III domain containing 1) was found to be related to hypoxia (Zhao et al., 2022) and to be associated with chemoradiation resistance and poor prognosis of gastric cancer, breast cancer, and colorectal cancer by multiple pathways (Ren et al., 2018; Zhong et al., 2018; Liu et al., 2019; Wei et al., 2021; Yunwen et al., 2021; Chen et al., 2022). Here, FNDC1 is linked to colorectal cancer.