Screening of primary DLBCL patient samples revealed that the expression of enzyme hexokinase 2(HK2) was significantly correlated with the DLBCL phenotype, and genetic knockdown studies demonstrated that HK2 is required for promoting growth of DLBCL under hypoxic stress (Bhalla et al., 2018). This evidence concerns the gene HK2 and diffuse large B-cell lymphoma.