Huang et al. (2019) revealed that long-lived ccRCC patients have high levels of Th17. The last hub TIIC in our signature was Tcm, a subset of memory T cells with key roles in the occurrence and development of cancers (Zhang et al., 2014). The expressional levels of CD4+/CD8+ Tcm were increased in gastric cancer patients after cancer surgery, revealing their tumor-suppressive roles (Zhang et al., 2014). This evidence concerns the gene CD4 and cancer.