AKT1 and cancer: These upregulated genes were subjected to KEGG pathway analysis, and the results showed that these upregulated genes were enriched in multiple pathways, including the PI3K-AKT and MAPK signaling pathways (Figure 6A), which have been demonstrated to contribute to the tumor growth and metastasis of various cancers (Manning & Toker, 2017; Peluso et al., 2019).