Gliotic Müller cells are recognized as the main secretion source of inflammatory cytokines (Eastlake et al., 2016) among which VEGF induces angiogenesis and vascular hyper-permeability thus playing as a major trigger of retinal and choroidal neovascularization leading to wet AMD (Tan et al., 2022). This evidence concerns the gene VEGFA and wet macular degeneration.