STAT3 and cancer: Zhao et al. demonstrated that PVT1 promotes gastric cancer angiogenesis through STAT3/VEGFA activation (Zhao et al., 2018); PCVT1’s impacts on cell proliferation, migration, invasion, and apoptosis raise cancer risk (Pan et al., 2018; Ghafouri-Fard et al., 2019; Wang et al., 2020), suggesting that it could be targeted in cancer therapy.