CASP3 and malignant colon neoplasm: Ginsenoside derivative 6d induced apoptosis in HCT-116 colon cancer cells by regulating the MEK/ERK signaling and mitochondrial pathways, significantly upregulating the expression of Cyt-c and Cl-caspase-3/9/PARP, regulating the expression levels of p53, p21, cyclin B1, and CDK1, and inducing G2/M phase block (Ma et al., 2021).