AKT1 and hepatocellular carcinoma: Shin et al. observed that C-K could promote tumor progression by inhibiting glycolysis and AKT/mTOR/c-Myc signaling and its downstream factors, hexokinase 2 and pyruvate kinase isozyme M2, inducing apoptosis in HepG2 and Huh7 HCC cells (Shin et al., 2021).