TLE3 and colorectal neoplasm: Furthermore, GRg3 reportedly inhibited the proliferation of colorectal tumors HCT116, HT29, and SW480 cells partly through downregulation of the C/EBPβ/NF-κB signaling pathway and significantly inhibited the growth of xenografts in nude mice after 3 weeks of intraperitoneal injection of GRg3 (Yang et al., 2017).