SIRT1 and hepatocellular carcinoma: Sirtuin belongs to the mammalian silent information regulator 1 family, and studies have shown that overexpression of sirtuin 1 (SIRT1) is associated with resistance to chemotherapy (Xiong et al., 2017), which may promote proliferation and drug resistance in HCC cells by affecting the PI3K pathway and MRP1 expression (Ling et al., 2017).