Yang et al. observed that GRg3 regulates the PTEN/β-PI3K/AKT pathway, upregulates PTEN and P53 expression, downregulates p-pi3k and AKT expression, inhibits cell proliferation, and suppresses the malignant development of gastric cancer SGC-7901 (Yang L et al., 2020). This evidence concerns the gene TLE3 and gastric cancer.