In pancreatic cancer metastasis, 20(S)-GRh2 effectively inhibited IL-6-induced signaling and STAT3 phosphorylation, MMP-1, -2, and -9 expression, suppressed migration and invasion of pancreatic cancer Bxpc3 cells (Li et al., 2021a), prevented degradation of the extracellular matrix and basement membrane, and inhibited EMT progression (Han et al., 2016). Here, IL6 is linked to familial pancreatic carcinoma.