In colorectal cancer cells, Liu et al. (Liu G et al., 2018) observed that GRh2 downregulated the expression of drug-resistant genes such as multidrug resistance-associated protein 1 (MRP1), multiple drug resistance (MDR1), lung-resistance-related protein (LRP) and Glutathione S-transferase (GST), enhanced the cytotoxicity of 5-FU against drug-resistant colorectal cancer cells (LoVo/5-FU and HCT-8/5-FU), and effectively reversed 5-FU resistance of CRC cells. Here, HPGDS is linked to colorectal cancer.