RUNX3 and colorectal cancer: GC-K significantly inhibits the growth of colorectal cancer cells by inhibiting the DNA expression and activity of methyltransferase 1, inducing demethylation of the RUNX3 promoter in HT-29 human colorectal cancer cells, causing RUNX3 mRNA and protein re-expression and localization in the nucleus (Salehi et al., 2020).