Deng et al. observed that Rh4 inhibited PD-L1 growth by suppressing aerobic glycolysis and regulating the AKT/mTOR pathway to inhibit PD-L1 expression and induce G1 phase arrest to inhibit growth, thus exerting anti-esophageal cancer effects (Deng M et al., 2020). The gene discussed is CD274; the disease is esophageal cancer.