MMP9 and familial pancreatic carcinoma: In pancreatic cancer cells, GRh2 also induces apoptosis in Bxpc-3 cells by upregulating Bax, caspase-3, and caspase-9, and downregulating Bcl-2, survivin, cyclin D1, MMP-2, and MMP-9 (Li et al., 2021a).