NR1I3 and hepatocellular carcinoma: High concentrations of PNT (80 μmol/L) can regulate HCC HepG2 cytochrome P3A4 (CYP3A4) expression through constitutive androstane receptor (CAR), The effects of CAR and pregnane X receptor (PXR) have an interactive dialogue, and after regulation, CAR can inhibit the PXR-CYP3A4 pathway (Hu, 2018; Hu Q et al., 2019).