20(R)-GRg3 inhibits the tumor stem cell properties of HT29 and SW620 colorectal cancer cells through the SNAIL signaling axis, downregulates the expression of stemness genes and EMT markers in CRC cells and suppresses motility and EMT in colorectal cancer (CRC) cells (Phi et al., 2019). The gene discussed is TLE3; the disease is colorectal carcinoma.