IL6 and pancreatic neoplasm: In pancreatic cancer metastasis, 20(S)-GRh2 effectively inhibited IL-6-induced signaling and STAT3 phosphorylation, MMP-1, -2, and -9 expression, suppressed migration and invasion of pancreatic cancer Bxpc3 cells (Li et al., 2021a), prevented degradation of the extracellular matrix and basement membrane, and inhibited EMT progression (Han et al., 2016).