CASP9 and gastric cancer: Aziz et al., in their study, observed that GRg3 was significantly induced in the apoptosis of SGC-7901 cells; GRg3 significantly increased the expression of proapoptotic proteins and triggered the activation of caspase-3, caspase-8, caspase-9, and PARP; subsequently, it inhibited the development of gastric cancer by upregulating SP1 and downregulating HSF1 and suppressing FUT4 expression (Aziz et al., 2016).