Li et al. observed that after GRg3 treatment, NHE1 expression could be reduced by the overall inhibition of the EGF-EGFR-er k1/2-HIF-1 signaling axis, promoting apoptosis and, thus, inhibiting the malignant progression of HCC (Li et al., 2018). Here, SLC9A1 is linked to hepatocellular carcinoma.