Ding et al. observed that Sijunzi tang, with GS as one of the main components, downregulates the expression of VEGFA, iNOS, COX-2 and Bax/Bcl2, regulates the PI3K/AKT pathway, and induces apoptosis to treat gastric cancer cells NUGC-4 (Ding et al., 2022). This evidence concerns the gene AKT1 and gastric cancer.