GRg3 inhibits VEGF-induced angiogenesis through the PI3K/Akt pathway and its downstream signaling molecules in HCC cells (Hu Q et al., 2019) and endometrial carcinoma (Cao et al., 2017) and regulates the expression of downstream regulators p70S6K and HIF-1α (Zhang X. et al., 2017). This evidence concerns the gene HIF1A and hepatocellular carcinoma.