In addition, Li et al. (Li et al., 2022a) observed that GRg1 significantly downregulated the expression level of sphingosine-1-phosphate lyase 1 (SGPL1) and increased the expression levels of p-Akt and p-ERK1/2 in steatosis HHL 5 cells, exerting an anti-apoptotic effect on nonalcoholic fatty liver cells. The gene discussed is SGPL1; the disease is non-alcoholic fatty liver.