In colorectal cancer cells, GRg3 can induce apoptosis in the colon cancer cell line HT-29 by activating the AMP-activated proteinase signaling pathway (Liu Z et al., 2021); GRg3(s) induces apoptosis in cancer stem cells by activating the caspase-3 and, caspase-9 pathways (Han et al., 2012); Lee et al. observed that GRg3 significantly inhibited NF-KB activity, activated caspase-3, and promoted the release of nitric oxide from the vascular endothelium in colon cancer cell lines, thereby inducing apoptosis in colon cancer cells (Lee et al., 2009). Here, CASP9 is linked to colonic neoplasm.