TP53 and gastric cancer: Yang et al. obseved that Rg3 suppressed the malignant development of gastric cancer SGC-7901 by regulating the PTEN/β-PI3K/AKT pathway, upregulating PTEN and P53 expression and downregulating p-pi3k and AKT expression to block the cell cycle in the G1 phase (Yang M et al., 2020); In addition, GS-Rd induced cell cycle arrest in the G0/G1 phase in gastric cancer cells SGC-7901 and MKN-45 by downregulating cell cycle protein D1 (Tian et al., 2020).