GRg3 reduces the expression of p-AKT, p-pi3K, MMP2, and MMP9, decreases lncRNA HOTAIR expression, and inhibits the proliferation and invasion of SMMC-7721 and SK-Hep-1 HCC cells by regulating the PI3k/AKT pathway (Pu et al., 2021). This evidence concerns the gene TLE3 and hepatocellular carcinoma.