Over-activated rapamycin complex 1 (mTORC1) signaling and elevated glycolysis down-regulate miR-26a and miR-101 in patients with SLE, resulting in increased expression of their target EZH2 (Barnas et al., 2019; Chen and Tsokos, 2021). This evidence concerns the gene EZH2 and systemic lupus erythematosus.