Isoflurane upregulated the phosphorylation of Beclin1, which formed the Beclin1-SLC7A11 complex, affected the activity of the cystine/glutamate transporter, and regulated ferroptosis in SH-SY5Y neuroblastoma cells by inhibiting the release of glutamate and decreasing intracellular GSH activity (Liu et al., 2019). The gene discussed is SLC7A11; the disease is neuroblastoma.