A fine balance among Bcl-2 family proteins leads to apoptotic regulation in cancer cells, as noted above, the simultaneous increase and decrease of Bax and Bcl-2 proteins respectively led to an almost 70% increase in the A549 cel lines whereas the increase was nearly 20% in H1299 cells in the Bax/Bcl-2 ratio (Figure 6E) at 80 μM as compared to control cells validating the induction of apoptosis after exposure to 18-αGA (Zhu et al., 2015). Here, BCL2 is linked to cancer.