Overexpression of EGFR can lead to unregulated activation of its downstream signaling pathways, which include PI3K/AKT, Ras-ERK/MAP kinase, Src, JAK/STAT, and PKC, thereby leading to uncontrolled proliferation, survival, migration of invasion of cancer cells (Seshacharyulu et al., 2012). Here, PRRT2 is linked to cancer.