According to these network topological properties, EGFR, PI3KR1, AKT1, MAPK1, SRC, and IGF1 were identified as the core targets of anti-NSCLC effects of 18α-GA; most of these targets have critical roles in cell proliferation, survival, cell cycle regulation, metastasis, and invasion. This evidence concerns the gene IGF1 and non-small cell lung carcinoma.